Biodegradable implant material comprising bioactive ceramic
AssigneesOsteoBiologics, Inc., USBiomaterials Corporation
InventorsBarbara D. Boyan, Gabriele Niederauer, Kristine Kieswetter, Neil C. Leatherbury, David C. Greenspan
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Abstract
Biodegradable polymeric therapeutic implant materials incorporating bioactive ceramics such as Bioglass.RTM. ceramic are provided. These implants provide increased mechanical properties and pH control, enabling the use of these materials to design porous and nonporous therapeutic implants used as cell scaffolds for healing of tissue defects or fixation devices, having desired degradation times, mechanical properties, elasticity and biocompatibility.
Claims27
A therapeutic implant material comprising a surface-passivated bioactive ceramic mixed with a biodegradable synthetic polymer in an amount sufficient to produce enhanced mechanical properties in said implant material.
A therapeutic implant material comprising a surface-passivated bioactive ceramic mixed with a biodegradable polymer in an amount sufficient to produce enhanced mechanical properties in said implant material, said material having a selected target porosity.
A method of making a substantially nonporous implant material comprising a surface-passivated bioactive ceramic mixed with a biodegradable polymer in an amount sufficient to produce enhanced mechanical properties in said implant material, said method comprising:
- (a) mixing said polymer with a polymer solvent;
- (b) mixing said bioactive ceramic with said dissolved polymer;
- (c) incubating said mixture of step (b) under pressure to produce said implant material.
A therapeutic implant material comprising a surface-passivated bioactive glass mixed with a biodegradable polymer in an amount sufficient to produce enhanced mechanical properties in said implant material.
A biodegradable film for application to a wound comprising a biodegradable polymer and between about 10 and about 70 percent of a surface-passivated bioactive ceramic.
Dependencies are inferred from the claim text.