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US 5,977,174 AGranted
Cholinergic compositions and uses thereof
AssigneeNeuromedica, Inc.
InventorsMatthews O. Bradley, Victor E. Shashoua, Charles S. Swindell, Nigel L. Webb
Life of this patent
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Abstract
The invention provides compositions that include conjugates of a cholinergic agent and a fatty acid, preferably cis-docosahexaenoic acid. The conjugates are useful in treating disorders resulting from cerebral ischemia including stroke.
Claims18
A method for treating stroke comprising
- administering to a subject in need of such treatment an amount of a covalent conjugate of a cholinergic agent and a fatty acid having 12-26 carbons in an amount effective to treat stroke.
A method for protecting cortical cells from ischemia-induced cell death comprising
- contacting the cortical cells which have been exposed to ischemic conditions sufficient to induce cell death with a covalent conjugate of a cholinergic agent and a fatty acid having 12-26 carbons in an amount effective to protect the cortical cells against cell death which would otherwise result from the ischemic conditions.
A method for selectively protecting cortical cells of a subject from stroke-induced cell death comprising
- administering to a subject in need of such treatment a covalent conjugate of a cholinergic agent and a fatty acid having 12-26 carbons in an amount effective to protect the cortical cells from stroke induced cell death.
Dependencies are inferred from the claim text.