Solid aldehyde and antimicrobial compositions useful as fixatives, preservatives and embalming agents
OwnerGerald W. Camienerinventor
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Abstract
Stable solid forms of preservative and embalming compositions are described which can be prepared by adding a sufficient amount of a chemical or chemicals containing at least one polar group capable of forming hydrogen and Van der Waal bonds with the reactive moieties of the aldehydes and antimicrobial agents in the preservative and embalming compositions. The amount of polar chemical(s) necessary to stabilize the reactive aldehydes and antimicrobial compounds/agents is based on a molar ratio of (i) polar groups in the stabilizing chemicals to (ii) reactive groups in the active preservative ingredient of at least 0.8.
Claims17
A solid or powdered preservative/fixative composition comprising:
- (a) a preservative-, fixative-, or embalming-effective amount of an agent having at least one reactive group selected from the group consisting of butanedialdehyde and diazolidinyl urea;
- and
- (b) an effective stabilizing amount of at least one compound having at least one polar group selected from the group consisting of citric acid, alkane sulfonic acid, glycolic acid, salicylic acid or a salt thereof;
- wherein the molar ratio of reactive group(s) of any preservative, fixative or embalming ingredient in the composition to polar group(s) of any other ingredient in the composition is at least 0.8 to 1;
- wherein said ingredients are released in an active form when said composition is contacted with an aqueous liquid, resulting in a solution that is suitable for preserving, fixing, or embalming biological materials.
A process for preserving, fixing or stabilizing biological material for microscopic examination which comprises adding an aqueous liquid to a solid or powdered composition comprising:
- (a) a preservative- or fixative-effective amount of an agent having at least one reactive group selected from the group consisting of glyoxal, butanedialde, and diazolidinyl urea;
- and
- (b) an effective stabilizing amount of at least one compound having at least one polar group selected from the group consisting of citric acid, alkane sulfonic acid, glycolic acid, salicylic acid or a salt thereof;
- wherein the molar ratio of reactive group(s) of any preservative or fixative ingredient in the composition to polar group(s) of any other ingredient in the composition is at least 0.8 to 7.
- thereby producing a solution wherein said ingredients of the solid or powdered composition are released in an active form suitable for preserving, fixing, and stabilizing biological material for microscopic examination;
- and contacting a biological material with said solution to render the biological material suitable for microscopic examination.
Dependencies are inferred from the claim text.