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US 5,976,574 AGranted
Processes for spray drying hydrophobic drugs in organic solvent suspensions
AssigneeInhale Therapeutic Systems
InventorMarc S. Gordon
Life of this patent
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Abstract
Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions or suspensions of the components and spray drying them simultaneously in a spray drier. The hydrophobic component may be dissolved in an organic solvent and the hydrophilic component suspended therein. The method provides dry powders having relatively uniform characteristics.
Claims16
A method for preparing a dry powder composition, said method comprising:
- preparing a solution of a hydrophobic component in an organic solvent or cosolvent system, wherein the hydrophobic component has a concentration in the range from 0.01 mg/ml to 10 mg/ml;
- suspending a hydrophilic component consisting of a hydrophilic excipient in the organic solvent or cosolvent system to form a suspension, wherein the hydrophilic component is suspended to a concentration in the range from 1 mg/ml to 100 mg/ml;
- and
- spray drying the suspension to form particles having an average particle size of below 10 .mu.m and comprising the hydrophilic and hydrophobic components.
1 more element
Dependencies are inferred from the claim text.