US 5,976,555 AGranted

Topical oil-in-water emulsions containing retinoids

AssigneeJohnson & Johnson Consumer Products, Inc.

InventorsJue-Chen Liu, Jonas C. T. Wang, Mohammed Yusuf, Norihiro Yamamoto, Satoshi Kazama, Christopher R. Stahl, Jean P. Holland, Kamran Mather, Margaret A. Aleles, Sachio Hamada, Curtis A. Cole

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Abstract

Skin care compositions comprising an oil-in-water emulsion base containing retinoids and possessing good physical and chemical stability. More particularly, said skin care compositions contain (a) an emulsifier system selected from the group consisting of: (i) a mixture of glyceryl stearate and polyethylene glycol 100 stearate; (ii) cetearyl alcohol and cetearyl glucoside; (iii) a mixture of a polyethylene glycol ethers of stearyl alcohol; and (iv) a mixture of sorbitan stearate and polysorbate 60; (b) a co-emulsifier selected from the group consisting of cetyl alcohol, stearyl alcohol and mixtures thereof; (c) an oil phase present in the amount of from about 5 to about 20 percent by weight of the total emulsion composition which contains (i) a light, dry absorbable oil and (ii) substantive, emollient oils or waxes, wherein the light, dry absorbable oil and the substantive oil or wax are present in a ratio of from about 1:3 for about 10:1.

Claims37

Dependent claims

A topical oil-in-water emulsion composition comprising:

a) an emulsifier system selected from the group consisting of:
i) a mixture of glyceryl stearate and polyethylene glycol 100 stearate;
ii) cetearyl alcohol and cetearyl glucoside;
iii) a mixture of a polyethylene glycol ether of stearyl alcohol of the formula:
CH.sub.3 (CH.sub.2).sub.10 CH.sub.2 (OCH.sub.2 CH.sub.2).sub.n OH
Wherein n is 21 and a polyethylene glycol ether of stearyl alcohol of the formula:
CH.sub.3 (CH.sub.2).sub.16 CH.sub.2 (OCH.sub.2 CH.sub.2).sub.n OH
Wherein n is 2;
and
iv) a mixture of sorbitan stearate and polysorbate 60 (a mixture of stearate esters of sorbitol and sorbitol anhydrides condensed with 20 moles of ethylene oxide);
b) a co-emulsifier selected from the group consisting of:
cetyl alcohol, stearyl alcohol and mixtures thereof;
c) an oil phase present in the amount of from about 2 to about 20 percent by weight of the total emulsion composition comprising:
i) a light, dry absorbable oil and
ii) substantive, emollient oils or waxes
wherein said light dry absorbable oil and said substantive oil or wax are present in a ratio of from about 1:3 to about 10:1;
d) a retinoid;
said composition having a pH of from about 4 to about 10.

15 more elements

Dependencies are inferred from the claim text.