Adjuvant composition containing synthetic hydrophobic lipopolysaccharide
AssigneeAmerican Cyanamid Company
InventorsLucas A.T. Hilgers, Peter-Paul L.I. Platenburg
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Abstract
According to the present invention the adjuvants comprise an emulsion containing at least one synthetic hydrophobic lipopolysaccharide, which can either or not be provided with anionic groups, while maintaining the overall hydrophobicity, an interface-forming constituent (such as an oil) and optionally an aqueous solute. In particular the adjuvant and vaccines prepared with it contain a lipopolysaccharide which had an HLB value of less then 9, more favorably less than 4.
Claims8
Adjuvant composition comprising at least one synthetic hydrophobic lipopolysaccharide, an interface-forming constituent and optionally an aqueous solute;
- wherein said lipopolysaccharide has a hydrophilic-lipophilic-balance (HLB) value with the range of 4 (inclusive) to 9 (exclusive).
Dependencies are inferred from the claim text.