Method for inhibiting the proliferation of epithelial lens cells and implantable lens therefor
AssigneePharmacia Corporation
InventorYves Courtois
Life of this patent
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Abstract
A conjugate of a polypeptide reactive with a fibroblast growth factor receptor and a cytotoxic agent is used for inhibiting the proliferation of epithelial lens cells, especially following extracapsular cataract surgery.
Claims14
A lens implant, comprising a lens implant and a conjugate, said conjugate comprising a cytotoxic agent and a polypeptide reactive with a fibroblast growth factor receptor, wherein the conjugate is provided on the surface of the lens.
A composition formulated for use in inhibiting proliferation of epithelial lens cells in the eye of a patient, comprising an effective amount of a cytotoxic conjugate, wherein:
- the cytotoxic conjugate comprises a cytotoxic agent and a polypeptide reactive with a fibroblast growth factor receptor;
- the composition is formulated for local application to a posterior lens capsule;
- and
- the amount is effective for inhibiting proliferation of epithelial lens cells in the eye and preventing opacification of the posterior lens capsule following extracapsular cataract surgery.
A method of inhibiting proliferation of epithelial lens cells, comprising, inserting a lens implant into an empty lens capsule of a patient, wherein a conjugate comprising a cytotoxic agent and a polypeptide reactive with a fibroblast growth factor (FGF) receptor is provided on a surface of the lens implant, and wherein the conjugate inhibits the proliferation of epithelial lens cells.
A method of treating secondary lens clouding following extracapsular cataract surgery comprising, administering a lens implant to the eye of a patient, wherein a conjugate comprising a cytotoxic agent and a polypeptide reactive with a fibroblast growth factor (FGF) receptor is provided on a surface of the lens implant, and wherein the conjugate prevents secondary lens clouding.
Dependencies are inferred from the claim text.