Diffusional implantable delivery system

A sustained release delivery system for delivering a beneficial agent formulated in a glassy sugar matrix at a predetermined rate, comprising:

• (a) a reservoir comprising said beneficial agent formulated in a glassy sugar matrix;
• and
• (b) a capillary channel in communication with said reservoir and the exterior of the system for delivering said beneficial agent from the system,
• said capillary channel having a cross-sectional area and a length selected to provide said predetermined rate.

A method of delivering a beneficial agent at a predetermined rate, said method comprising positioning a sustained release diffusional delivery system at a location in need of such beneficial agent, said sustained release diffusional delivery system comprising:

• (a) a reservoir that encloses said beneficial agent, an entirety of said reservoir that encloses said beneficial agent being impermeable and non-porous to fluids external of said reservoir during delivery of the beneficial agent;
• and
• (b) a capillary channel in communication with said reservoir and the exterior of the system for delivering said beneficial agent from the system;
• said capillary channel having a cross-sectional area and a length selected to provide said predetermined rate.

A method of delivering a beneficial agent formulated in a glassy sugar matrix at a predetermined rate, said method comprising positioning a sustained release delivery system at a location in need of the beneficial agent formulated in a glassy sugar matrix, said sustained release delivery system comprising:

• (a) a reservoir comprising said beneficial agent;
• and
• (b) a capillary channel in communication with said reservoir and the exterior of the system for delivering said beneficial agent from the system,
• said capillary channel having a cross-sectional area and a length selected to provide said predetermined rate.

A method of preparing a sustained release delivery system for delivering a beneficial agent at a predetermined rate, said method comprising the steps of:

• (a) providing a reservoir that encloses the beneficial agent, an entirety of said reservoir that encloses said beneficial agent being impermeable and non-porous to fluids external of said reservoir during delivery of the beneficial agent;
• (b) filling said reservoir with the beneficial agent;
• and
• (c) providing the reservoir with a diffusion controller,
• said diffusion controller comprising a capillary channel having a cross-sectional area and a length selected to provide said predetermined rate.

A method of preparing a sustained release delivery system for delivering a beneficial agent formulated in a glassy sugar matrix at a predetermined rate, said method comprising the steps of:

• (a) providing a reservoir;
• (b) providing a beneficial agent formulated in a glassy sugar matrix in said reservoir;
• and
• (c) providing the reservoir with a diffusion controller,
• said diffusion controller comprising a capillary channel having a cross-sectional area and a length selected to provide said predetermined rate.