Drug releasing surgical implant or dressing material
AssigneeThe Unites States of America as represented by the Secretary of the Army
InventorsDuncan H. Haynes, Ben H. Bodeker, Mark D. Kline
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Abstract
A surgical implant or external wound dressing which functions as both a hemostat and a device to safely and effectively deliver any of a number of pharmaceuticals to targeted tissue at a controlled rate is disclosed. The device generally comprises a carrier in the form of fibers, sutures, fabrics, cross-linked solid foams or bandages, a pharmaceutical in solid micoparticulate form releasably bound to the carrier fibers, and a lipid adjuvant which aids the binding of the microparticles to the fibers as well as their function in the body.
Claims10
A drug delivering surgical device for internal or external use comprising:
- a carrier comprising a pharmaceutically acceptable porous, fibrous matrix for releasably securing coated drug microparticles therein, said fibers having diameters of between about 0.1 micrometers to about 100 micrometers;
- wherein said coated drug microparticles between about 20 nanometers to about 20 micrometers in size, releasably bound to said fibrous matrix by attachment or entrapment therein;
- said fibers and said drug microparticles are each coated with a coating agent selected from the group consisting of non-crosslinked collagen and gelatin, carboxymethylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, polyethylene glycol, povidone, benzalkonium chloride, benzethonium chloride, or long-chain alkylamines.
Dependencies are inferred from the claim text.