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US 5,969,184 AGranted
Amide compounds
AssigneeSmithKline Beecham Corporation
InventorsJerry Leroy Adams, Peter William Sheldrake, Timothy Francis Gallagher, Ravi Shanker Garigipati, Paul Elliot Bender, Jeffrey Charles Boehm, Joseph Sisko, Zhi-Qiang Peng, John C. Lee
Life of this patent
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Abstract
The present invention is directed to the novel intermediate compounds of the formula: ##STR1## wherein, interalia, R.sub.4 is a substituted phenyl or an optionally substituted napthyl derivative.
Claims8
A compound of the formula ##STR17## wherein R.sub.4 is a phenyl substituted one more times independently by fluorine SR.sub.5, SOR.sub.5, or halo-substituted C.sub.1-4 alkyl;
- R.sub.5 is hydrogen, C.sub.1-4, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl or NR.sub.7 R.sub.17, excluding the moieties SR.sub.5 being SNR.sub.7 R.sub.17 and SOR.sub.5 being SOH;
- R.sub.7 and R.sub.17 is each independently selected from hydrogen or C.sub.1-4 alkyl or R.sub.7 and R.sub.17 together with the nitrogen to which they are attached from heterocyclic ring of S to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR.sub.15 ;
- R.sub.10 is hydrogen C.sub.1-4 alkyl;
- R.sub.12 is hydrogen or R.sub.16 ;
- R.sub.15 is R.sub.10 or C(Z)-C.sub.1-4 alkyl;
- R.sub.16 is C.sub.1-4 alkyl, halo-substituted-C.sub.1-4 alkyl, or C.sub.3-7 cycloalkyl;
- and
- Z is oxygen or sulfur.
5 more elements
Dependencies are inferred from the claim text.