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US 5,969,181 AGranted
Preparation of salts of pharmaceutical active substances which have acidic groups
OwnerJorg Breitenbach, Joerg Rosenberg +4inventors
InventorsJorg Breitenbach, Joerg Rosenberg, Jorg Neumann, Jurgen Zeidler, Dirk Simon, Ralph Diener
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Abstract
A process for preparing salts of pharmaceutical active substances which have acidic groups by reacting the carboxylic acids with a base in the melt, wherein the acids are reacted with at least the stoichiometric amount of a base in an extruder.
Claims6
A process for preparing salts of pharmaceutical active substances which have acidic groups by reacting the carboxylic acids with a base in the melt, wherein the acids are reacted with at least the stoichiometric amount of a base in an extruder.
Dependencies are inferred from the claim text.