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US 5,969,161 AGranted
5-O-deaominyl 6-O-methyl erythronolide a derivatives, method for preparing same and application thereof for preparing biologically active products
AssigneeHoechst Marion Roussel, Inc.
InventorsAlain Bonnet, Michel Delthil, Alain Mazurie
Life of this patent
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Abstract
A subject of the invention is the compounds of formula (I): ##STR1## in which OR.sub.1, OR.sub.2 and OR.sub.3 represent hydroxyl radicals blocked in the form of easily cleavable radicals. The compounds of formula (I) can be used to prepare antibiotic products.
Claims13
The compounds of formula (I):
- ##STR15## in which:
- either R.sub.1 represents an alkyl radical containing up to 8 carbon atoms substituted by one or more alkyl radicals containing up to 8 carbon atoms, or by one or more aryl radicals containing up to 14 carbon atoms,
- or R.sub.1 represents an aryl radical containing up to 14 carbon atoms, optionally substituted by one or more alkyl, alkenyl or alkynyl radicals containing up to 8 carbon atoms, alkoxy or alkylthio radicals containing up to 8 carbon atoms, nitro, CF.sub.3 radicals or by one or more halogen atoms,
- or R.sub.1 represents a radical:
- ##STR16## in which Ra represents an alkyl or alkoxy radical containing up to 8 carbon atoms,
- Rb represents an alkyl radical containing up to 8 carbon atoms, optionally substituted by a heteroatom,
- Rc represents a hydrogen atom or an alkyl radical containing up to 8 carbon atoms,
- R.sub.2 and R.sub.3, identical or different, represent a trialkylsilyl radical in which the alkyl radical contains up to 8 carbon atoms, ##STR17## in which R'a, R'b, R'c and Rd represent an alkyl radical containing up to 8 carbon atoms, or an aralkyl radical containing up to 8 carbon atoms, optionally substituted by one or or more of the substituents indicated above for R.sub.1.
5 more elements
Dependencies are inferred from the claim text.