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US 5,969,157 AGranted
Process for the synthesis of benzothiophenes
AssigneeEli Lilly and Company
InventorJeffrey Thomas Vicenzi
Life of this patent
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Abstract
The instant invention provides improved processes for preparing benzothiophenes utilizing methanesulfonic acid.
Claims11
A process for preparing a compound of formula Ib ##STR7## wherein the R groups are the same or different and represent C.sub.1 -C.sub.6 alkyl,
- which comprises:
- cyclizing a dialkoxy compound of formula II ##STR8## in the presence of methanesulfonic acid.
In a process for preparing a compound of formula III wherein:
- R.sub.1 and R.sub.2 are independently C.sub.1 -C.sub.6 alkyl, or combine to form, with the nitrogen to which they are attached, piperidinyl, pyrrolidinyl, methylpyrrolidinyl, dimethylpyrrolidinyl, or hexamethyleneimino, or the pharmaceutically acceptable salts or solvates thereof;
- the improvement which comprises:
- cyclizing a compound of formula II ##STR11## wherein the R groups are the same or different, and represent C.sub.1 -C.sub.6 alkyl, in the presence of methanesulfonic acid.
Dependencies are inferred from the claim text.