Oxazolidin-2-one derivatives, preparation method therefor and therapeutical use thereof
AssigneeSynthelabo
InventorsSamir Jegham, Frederic Puech, Philippe Burnier, Danielle Berthon, Odile Leclerc
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AssigneeSynthelabo
InventorsSamir Jegham, Frederic Puech, Philippe Burnier, Danielle Berthon, Odile Leclerc
Estimating the term…
Compounds derived from oxazolidin-2-one of formula (I) ##STR1## in which: R.sub.1 represents a hydrogen atom, an alkyl group, a hydroxyalkyl group, a fluoroalkyl group, a hydroxyfluoroalkyl group, a cyanoalkyl group, a substituted or unsubstituted phenyl group, a substituted or unsubstituted phenylmethyl group or an R.sub.3 A- group in which R.sub.3 is a cycloalklyl or cyclooxyalkyl group which is unsubstituted or substituted by a hydroxyl group and A is a --CH.sub.2 or --CH.sub.2 --CH.sub.2 radical, R.sub.2 represents a hydrogen atom or a methyl group, X represents an oxygen or sulphur atom or an NR.sub.4 group where R.sub.4 is an alkyl group or a hydrogen atom, and Z represents an oxygen atom or a --CH.dbd.CH or --CH.sub.2 --CH.sub.2 group, their process of preparation and their applications in therapeutics.
A compound of formula (I) in which:
(R)-5 -(Methoxymethyl)-3-[6-(phenylmethoxy)benzofuran-3-yl]oxazolidin-2-one or its enantiomer.
(R)-5-(Metho xymethyl)-3-[6-(4,4,4-trifluorobutoxy)benzofuran-3-yl]oxazolidin-2-one or its enantiomer.
(R,R)-5-Meth oxymethyl)-3-[6-(4,4,4-trifluoro-3-hydroxybutoxy)benzofuran-3 -yl]oxazolidin-2-one or its diastereoisomers.
(R,R)-5-(Hydroxymethyl)-3-[6-(4,4,4-triflu oro-3-hydroxybutoxy)benzofuran-3-yl]oxazolidin-2-one or its diastereoisomers.
(R)-5-(Methoxy methyl)-3-[6-(5,5,5-trifluoropentyl)benzofuran-3-yl]oxazolidin-2-one or its enantiomer.
(R)-5-(M ethoxymethyl)-3-[6-(5,5,5-trifluoro-4-hydroxypent-1-enyl)benzofuran-3-yl]-o xazolidin-2-one, its diastereoisomers or their cis or trans isomers.
(R)-5-(Methoxymethyl)-3-[6-(phenylmethoxy)benzo[b]thien-3-yl]oxa zolidin-2-one or its enantiomer.
Dependencies are inferred from the claim text.