Radiolabeled pyridyl-7-azabicyclo[2,2,1]heptanes
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsEdythe D. London, Alane S. Kimes, Andrew Horti, Robert F. Dannals, Michael Kassiou
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Abstract
The present invention is directed to radiolabeled epibatidine analogues, specifically FPH labeled with radioisotopes of fluorine and/or carbon. These radiolabeled epibatidine compounds are used to noninvasively image and quantify nicotinic cholinergic receptors in the living brain for both research studies and the diagnosis of neurodegenerative diseases.
Claims13
A compound of the formula ##STR3## wherein R is selected from the group consisting of hydrogen, C.sub.1 -C.sub.6 alkyl, halo C.sub.1 -C.sub.6 alkyl, aryl, and aryl C.sub.1 -C.sub.6 alkyl, R.sup.1 is selected from the group consisting of hydrogen and C.sub.1 -C.sub.6 alkyl, and X is selected from the group consisting of hydrogen, halo, and halo C.sub.1 -C.sub.6 alkyl, wherein at least one of R, R.sup.1, and X is radiolabeled.
Dependencies are inferred from the claim text.