US 5,969,140 A · Naphthalene derivatives, process for the preparation thereof, and intermediates therefor

Abstract

Naphthalene derivatives of the formula [I]: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are each H, protected or unprotected OH, one of R.sup.3 and R.sup.4 is protected or unprotected hydroxymethyl, and the other is H, lower alkyl, or protected or unprotected hydroxymethyl, R.sup.5 and R.sup.6 are the same or different and are each H, substituted or unsubstituted lower alkyl, substituted or unsubstituted phenyl or protected or unprotected NH.sub.2, or both combine together with the adjacent N to form substituted or unsubstituted heterocyclic group, and pharmaceutically acceptable salts thereof, these compounds showing excellent bronchoconstriction inhibitory activity, and hence, being useful in the prophylaxis or treatment of asthma.

Claims23

Dependent claims

A naphthalene derivative of the formula (I):

##STR171## wherein R.sup.1 and R.sup.2 are the same or different and are each a hydrogen atom or a protected or unprotected hydroxy group;
either one of R.sup.3 and R.sup.4 is a protected or unprotected hydroxy-substituted methyl group, and another is a hydrogen atom, a lower alkyl group, or a protected or unprotected hydroxy-substituted methyl group;
R.sup.5 and R.sup.6 both bond at their termini and combine with the adjacent nitrogen atom to form a substituted or unsubstituted quinolyl group, which may be partially or wholly hydrogenated, and a pharmaceutically acceptable salt thereof.

Dependencies are inferred from the claim text.

Naphthalene derivatives, process for the preparation thereof, and intermediates therefor

Life of this patent

Naphthalene derivatives, process for the preparation thereof, and intermediates therefor

Life of this patent

Abstract

Claims23