Pyrrolidinone derivatives
AssigneeMitsui Chemicals, Inc.
InventorsNaruyoshi Mita, Hiroshi Nagase, Hajime Iizuka, Takahisa Oguchi, Kazuya Sakai, Kazutoshi Horikomi, Takaichi Miwa, Shinji Takahashi
Life of this patent
Estimating the term…
Abstract
Since a compound represented by general formula (1), its pharmaceutically acceptable salt and a hydrate of the pharmaceutically acceptable salt have high antipsychotic activity, they may be used as an active ingredient for preparation of an antipsychotic. ##STR1## Also provided are an optical resolution method of the above compound and an intermediate for preparation of the compound.
Claims15
A pyrrolidinone derivative represented by general formula (1) or a pharmaceutically acceptable salt thereof or a hydrate of the pharmaceutically acceptable salt:
- ##STR14## wherein R.sup.1 is hydrogen or a halogen;
- R.sup.2 is hydrogen, a C.sub.1-3 alkyl, a C.sub.2-3 alkenyl or a C.sub.2-3 alkynyl;
- and n is an integer of 2 to 3.
An intermediate salt for the preparation of an optically active pyrrolidinone derivative or a pharmaceutically acceptable salt thereof or a hydrate of the pharmaceutically acceptable salt, said intermediate salt consisting of the pyrrolidinone derivative represented by general formula (2) and optically active mandelic acid or optically active tartaric acid:
- ##STR17## wherein R.sup.1 is chlorine;
- R.sup.2 is methyl;
- and n is 2.
Dependencies are inferred from the claim text.