Benzylamidine derivatives with serotonin receptor binding activity

Abstract

This invention relates to compounds having serotonin receptor binding activity, to pharmaceutical compositions containing them and to their medical use, particularly in the treatment of CNS conditions. Described herein are compounds which have the general formula: ##STR1## wherein R.sup.1 is selected from a group of Formula i and ii: ##STR2## n is 1-3; R.sup.2 is selected from H and C.sub.1-6 alkyl; R.sup.3 is selected from H and C.sub.1-6 alkyl; R.sup.4 is selected from C.sub.1-6 alkyl, halo, phenyl, amino and nitro; R.sup.5 is selected from H, C.sub.1-6 alkyl and arylalkyl; R.sup.6 is selected from H or a alkylene group which is bonded to R.sup.4 to form the naphthalene ring skeleton; and salts, hydrates and solvates thereof. Also described is the use of these compounds as pharmaceuticals to treat indications where stimulation of subtypes of the serotonin receptor is implicated, such as migraine.

Dependencies are inferred from the claim text.