Meningococcal polysaccharide conjugate vaccines
AssigneeNational Research Council of Cananda
InventorsHarold J. Jennings, Robert Pon, Michele Lussier, Francis Michon
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Abstract
The invention relates to chemically-modified group B polysaccharides of Neisseria meningitidis. The invention also provides vaccines in which the respective modified polysaccharides are conjugated to a protein carrier, and the like. More specifically, the present invention provides novel group B meningococcal unsaturated N-acyl derivative polysaccharides, novel conjugates of the group B meningococcal unsaturated N-acyl derivative polysaccharides, pharmaceutical compositions comprising conjugate molecules of group B meningococcal unsaturated N-acyl derivative polysaccharide fragments covalently bound to proteins, and the use of these compositions as vaccines.
Claims9
A modified group B meningococcal polysaccharide wherein the N-acetyl groups are substituted with an N-acyl derivative as in Formula (I):
- ##STR4## wherein R.sub.1 is a C.sub.3 -C.sub.4 unsaturated alkyl group.
Dependencies are inferred from the claim text.