Mutants of the RB and P53 genes
AssigneeResearch Development Foundation
InventorYuen Kai Fung
Life of this patent
Estimating the term…
Abstract
The present invention provides mutants of the Rb and p53 genes and methods utilizing these mutants therapeutically. Along with mutated Rb genes and p53 genes, the present invention provides plasmids containing a mutated Rb gene or a p53 gene. In addition, the present invention provides cells transfected with the plasmids of the present invention. Moreover, the present invention provides for methods of treating a variety of pathophysiological cell proliferative diseases.
Claims2
An isolated DNA molecule, wherein said molecule is a synthetic mutated Rb gene encoding a mutated functionally active retinoblastoma protein, wherein said Rb gene is mutated by changing nucleotides that encode for amino acids in conserved homology regions selected from the group of regions P1(SEQ ID No. 4) P3 (SEQ ID No. 6) and P5 (SEQ ID No. 8) to encode non-conservative amino acids.
Dependencies are inferred from the claim text.