Modified protein kinase a-specific oligonucleotide
AssigneeHybridon, Inc.
InventorSudhir Agrawal
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Abstract
Disclosed are synthetic, modified oligonucleotides complementary to, and capable of down-regulating the expression of, nucleic acid encoding protein kinase A subunit RI.sub.60. The modified oligonucleotides have from about 15 to about 30 nucleotides and are hybrid, inverted hybrid, or inverted chimeric oligonucleotides. Also disclosed are therapeutic compositions containing such oligonucleotides and methods of using the same.
Claims23
A synthetic, modified oligonucleotide complementary to, and capable of down-regulating the expression of, nucleic acid encoding protein kinase A subunit RI.sub..alpha., the modified oligonucleotide having from about 15 to about 30 nucleotides and being an inverted hybrid or inverted chimeric oligonucleotide,
- the inverted hybrid oligonucleotide comprising a region of at least four ribonucleotides flanked by 3' and 5' flanking deoxyribonucleotide regions of at least two deoxyribonucleotides,
- and the inverted chimeric oligonucleotide comprising an oligonucleotide nonionic region of at least four nucleotides flanked by two oligonucleotide phosphorothioate regions.
An oligonucleotide consisting essentially of the nucleotide sequence set forth in SEQ ID NO:4.
Dependencies are inferred from the claim text.