Self-aligning peptides modeled on human elastin and other fibrous proteins
AssigneesThe Hospital for Sick Children, Protein Specialties, Ltd.
InventorsAser Rothstein, Fred W. Keely, Steven J. Rothstein
Life of this patent
Estimating the term…
Abstract
A polypeptide is provided that has a secondary structure characterized by at least three beta-sheet/beta-turn structures, and that is not a naturally occurring fibrous protein. Such polypeptides, illustrated by one modeled on elastin, are useful in prosthesis.
Claims22
A polypeptide that comprises at least three beta-sheet/beta-turn structures and at least one amino acid residue that participates in cross-linking, and that is not a naturally occurring fibrous protein.
A polypeptide having the primary structure of a portion of a naturally occurring fibrous protein and a secondary structure comprising at least three beta-sheet/beta-turn structures, wherein:
- (A) the polypeptide comprises at least one amino acid residue that participates in cross-linking;
- (B) each of the beta-sheet/beta-turn structures comprises from 3 to about 7 amino acid residues and (C) the polypeptide is not a naturally occurring fibrous protein.
Dependencies are inferred from the claim text.