ABL-interactor protein
AssigneeDuke University
InventorsAnn Marie Pendergast, Zonghan Dai
Life of this patent
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Abstract
The present invention relates to a protein that interacts with the cAbl protein tyrosine kinase and to a nucleic acid sequence encoding same. The invention also relates to complexes of the protein of the invention and cAbl and to the use of such complexes in the identification of therapeutic and diagnostic agents.
Claims13
An isolated Abi protein consisting of the sequence given in SEQ ID NO:5, or a portion of said Abi protein consisting of 10 or more consecutive amino acids of the sequence given in SEQ ID NO:5.
An isolated Abi protein consisting of the sequence given in SEQ ID NO:5, or a portion of said protein consisting of 100 or more consecutive amino acids of the sequence given in SEQ ID NO:5.
An isolated Abi protein consisting of the sequence given in SEQ ID NO:5, or a portion of said Abi protein consisting of at least the homeodomain homologous region of the sequence given in SEQ ID NO:5.
An isolated Abi protein consisting of the sequence given in SEQ ID NO:5, or a portion of said Abi protein that consists of at least amino acid residues 101 to 401 of the sequence given in SEQ ID NO:5.
An isolated Abi protein consisting of the sequence given in SEQ ID NO:5 or a portion of said Abi protein that consists of at least amino acid residues 158 to 401 of the sequence given in SEQ ID NO:5.
An isolated protein having the amino acid sequence given in SEQ ID NO:5 .
Dependencies are inferred from the claim text.