Growth factor analogs
AssigneeThe Secretary of State for Defence
InventorsDerek W. Anderson, John M. Mellor, Nigel G. J. Richards, Karen J. Sargood, David L. Turner, Ram P. Sharma, Donna E. Davies, Stephen G. Chamberlin, Audrey Richter
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Abstract
A peptide having growth factor type activity (mitogenic and agonist/antagonist for the EGF receptor) which is a TGF-.alpha. analog but contains a bicyclic Pro analog (for instance D-2-azabicyclo[2,2,1]heptane-3-carboxylic acid), an N-terminal Phe or Trp residue, and a disulfide bridge.
Claims16
A peptide having growth factor receptor activity and comprising an amino acid sequence corresponding to Sequence I.D. No. 3 or a sequence wherein the amino acids of Sequence I.D. No. 3 are replaced by conservative substitutions or a sequence having 90% homology to either of these peptide sequences wherein the amino acid at position 10 of Sequence I.D. No. 3 or the sequences conservatively substituted or homologous thereto is a bicyclic proline analog and in that a disulphide bridge is provided between the cysteine residues at positions 1 and 12.
A peptide having growth factor receptor activity and comprising an amino acid sequence corresponding to Sequence I.D. No. 4 or a sequence wherein the amino acids of Sequence I.D. No. 4 are replaced by conservative substitutions or a sequence having 90% homology to either of these peptide sequences wherein the amino acid at position 1 of Sequence I.D. No. 4 or the sequences conservatively substituted or homologous thereto is a phenylalanine or tryptophan and at position 11 is a bicyclic proline analog and in that a disulphide bridge is provided between the cysteine residues at positions 2 and 13.
A peptide comprising an amino acid sequence corresponding to Sequence I.D. No. 3 or a sequence wherein the amino acids of Sequence I.D. No. 3 are replaced by conservative substitutions wherein the amino acid at position 10 of Sequence I.D. No. 3 or the sequences conservatively substituted is a bicyclic proline analog and in that a disulphide bridge is provided between the cysteine residues at positions 1 and 12.
A peptide comprising an amino acid sequence corresponding to Sequence I.D. No. 4 or a sequence wherein the amino acids of Sequence I.D. No. 4 are replaced by conservative substitutions wherein the amino acid at position 1 of Sequence I.D. No. 4 or the sequences conservatively substituted or homologous thereto is a phenylalanine or tryptophan and at position 11 is a bicyclic proline analog and in that a disulphide bridge is provided between the cysteine residues at positions 2 and 13.
Dependencies are inferred from the claim text.