Conotoxin peptides
AssigneesThe Salk Institute for Biological Studies, University of Utah Research Foundation
InventorsKi-Joon Shon, William R. Gray, John Dykert, Doju Yoshikami, Maren Watkins, David R. Hillyard, Jean E. F. Rivier, Baldomero M. Olivera
Life of this patent
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Abstract
Substantially pure conotoxin peptides are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular skeletal nAChRs to the exclusion of neuronal nAChRs. The peptides are of such length that they can be made by chemical synthesis, and the preferred peptides have formula: H-His-4Hyp-4Hyp-Cys-Cys-Leu-Tyr-Gly-Lys-Cys-Arg-Arg-Tyr-4Hyp-Gly-Cys-Ser-S er-Ala-Ser-Cys-Cys-Gln-Xaa.sub.24 -NH.sub.2 wherein Xaa.sub.24 is Arg or Gly.
Claims11
A substantially pure conotoxin peptide having the formula (SEQ ID NO:1):
- H-His-Xaa.sub.2 -Xaa.sub.3 -Cys-Cys-Leu-Tyr-Gly-Lys-Cys-Arg-Arg-Tyr-Xaa.sub.14 -Gly-Cys-Ser-Ser-Ala-Ser-Cys-Cys-Gln-Xaa.sub.24 -NH.sub.2 wherein Xaa.sub.2, Xaa.sub.3 and Xaa.sub.14 are independently Pro or 4Hyp and Xaa.sub.24 is Arg or Gly.
Dependencies are inferred from the claim text.