Anti-paramyxovirus screening method and vaccine
AssigneeEmory University
InventorsRichard William Compans, Qizhi Yao
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Abstract
A method is provided for detecting whether a test composition can inhibit cell fusion mediated by paramyxovirus infection. A method is also provided for identifying an antiviral peptide capable of inhibiting paramyxovirus-induced cell fusion. The methods are based on the discovery that the hemagglutination and fusion-inducing proteins of paramyxoviruses interact to form a complex termed HN:F, that is prerequisite to cell fusion. Antibodies to HN:F provide a novel means of providing improved immunity against paramyxovirus infection.
Claims4
A peptide having the amino acid sequence of SEQ ID NO:20.
A peptide having the amino acid sequence of SEQ ID NO:21.
A peptide having the amino acid sequence of SEQ ID NO:22.
A peptide having the amino acid sequence of SEQ ID NO:23.
Dependencies are inferred from the claim text.