Restricted 9-cis retinoids

A compound of Formula I:

• ##STR63## wherein:
• A, B and C are CH, CH.sub.2, O, or S wherein no more than one heteroatom is present;
• D is (CH).sub.m, and m is an integer 0 to 1;
• or D is (CH.sub.2).sub.n, and n is an integer 0 to 2;
• the dotted line, -----, represents the presence or absence of a double bond whereby if only one double bond is present, it is disposed to the a-b position;
• or if multiple double bonds are present they are in a conjugated position to produce an aromatic ring;
• R is hydrogen, methyl, ethyl, t-butyl, or trifluoromethyl;
• Ar is:
• a moiety of the formula:
• ##STR64## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are hydrogen, (C.sub.1 -C.sub.3)alkyl, (C.sub.1 -C.sub.3)alkoxy or trifluoromethyl;
• and
• X is CH.sub.2 OH, CHO, CO.sub.2 H, CN, CH.sub.2 CONH.sub.2, or a moiety of the formula:
• ##STR65## and R.sub.8 is straight or branched (C.sub.1 -C.sub.8)alkyl, or ##STR66## wherein R.sub.9 is hydrogen, straight or branched (C.sub.1 -C.sub.10)alkyl, glycosyl, 2-methoxyethyl, 2-dimethylaminoethyl, (1,2 or 3)-pyridyl, or (1,2 or 3)-pyridylmethyl;
• Y is hydrogen,
• and the pharmaceutically acceptable salts and esters.

A compound of Formula I:

• ##STR67## wherein:
• A is CH or CH.sub.2 ;
• B and C are CH, CH.sub.2, O, or S wherein no more than one heteroatom is present;
• D is (CH).sub.m, and m is an integer 0 to 1;
• or D is (CH.sub.2).sub.n, and n is an integer 0 to 2;
• the dotted line, -----, represents the presence or absence of a double bond whereby if only one double bond is present, it is disposed to the a-b position;
• or if multiple double bonds are present they are in a conjugated position to produce an aromatic ring;
• R is hydrogen, methyl, ethyl, t-butyl, or trifluoromethyl;
• Ar is:
• a moiety of the formula:
• ##STR68## wherein R.sub.5 is hydrogen, (C.sub.1 -C.sub.3)alkyl, methoxy or trifluoromethyl;
• R.sub.6 is hydrogen, methyl or ethyl, and
• X is CH.sub.2 OH, CHO, CO.sub.2 H, CN, CH.sub.2 CONH.sub.2, or a moiety of the formula:
• ##STR69## and R.sub.8 is straight or branched (C.sub.1 -C.sub.8)alkyl, or ##STR70## wherein R.sub.9 is hydrogen, straight or branched (C.sub.1 -C.sub.10)alkyl, glycosyl, 2-methoxyethyl, 2-dimethylaminoethyl, (1,2 or 3)-pyridyl, or (1,2 or 3)-pyridylmethyl;
• Y is hydrogen,
• and the pharmaceutically acceptable salts and esters.

A compound of Formula I:

• ##STR71## wherein:
• A is CH or CH.sub.2 ;
• B and C are CH, CH.sub.2, O, or S wherein no more than one heteroatom is present;
• D is (CH).sub.m, and m is an integer 0 to 1;
• or D is (CH.sub.2).sub.n, and n is an integer 0 to 2;
• the dotted line, -----, represents the presence or absence of a double bond whereby if only one double bond is present, it is disposed to the a-b position;
• or if multiple double bonds are present they are in a conjugated position to produce an aromatic ring;
• R is hydrogen, methyl, ethyl, t-butyl, or trifluoromethyl;
• Ar is:
• a moiety of the formula:
• ##STR72## wherein R.sub.6 is hydrogen, methyl or ethyl;
• R.sub.7 is hydrogen, methyl or ethyl;
• and
• X is CH.sub.2 OH, CHO, CO.sub.2 H, CN, CH.sub.2 CONH.sub.2, or a moiety of the formula:
• ##STR73## and R.sub.8 is straight or branched (C.sub.1 -C.sub.8)alkyl, or ##STR74## wherein R.sub.9 is hydrogen, straight or branched (C.sub.1 -C.sub.10)alkyl, glycosyl, 2-methoxyethyl, 2-dimethylaminoethyl, (1,2 or 3)-pyridyl, or (1,2 or 3)-pyridylmethyl;
• Y is hydrogen,
• and the pharmaceutically acceptable salts and esters.