Stimulation of nerve growth and/or vitality
AssigneeCalifornia Institute of Technology
InventorPaul H. Patterson
Life of this patent
Estimating the term…
Abstract
The protein, cholinergic neuronal differentiation factor (CDF), also known as leukemia inhibitory factor (LIF), is described, together with the use of the polypeptide to stimulate neuron growth and survival in animals either by direct administration or by autotransplantation of adrenal medullary cells converted to the cholinergic phenotype.
Claims4
A method for treating conditions requiring cholinergic nerve growth comprising administering cholinergic differentiation factor/leukemia inhibitory factor (CDF/LIF) to an animal, to adrenal medullary chromaffin cells, or to injured nerves, in an amount effective to stimulate cholinergic neuronal growth.
A method for inducing cholinergic nerve growth comprising administering cholinergic differentiation factor/leukemia inhibitory factor (CDF/LIF) to an animal, to adrenal medullary chromaffin cells, or to injured nerves, in an amount effective to stimulate cholinergic nerve growth.
Dependencies are inferred from the claim text.