Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells

A polynucleotide sequence as set forth in SEQ D NO:9.

A polynucleotide sequence at least 70% homologous to SEQ ID NO:9, as determined using default parameters of a DNA sequence analysis software package developed by the Genetic Computer Group (GCG) at the University of Wisconsin, wherein said polynucleotide sequence encodes a polypeptide having heparanase catalytic activity.

A vector comprising a polynucleotide sequence encoding a polypeptide having heparanase catalytic activity, wherein said polypeptide shares 70% homology with SEQ ID NO:10, as determined using default parameters of a DNA sequence analysis software package developed by the Genetic Computer Group (GCG) at the University of Wisconsin.

A host cell comprising an exogenous polynucleotide fragment including a polynucleotide sequence encoding a polypeptide having heparanase catalytic activity, wherein said polypeptide shares 70% homology with SEQ ID NO:10 as determined using default parameters of a DNA sequence analysis software package developed by the Genetic Computer Group (GCG) at the University of Wisconsin.

A host cell expressing a recombinant heparanase, wherein said recombinant heparanase shares 70% homology with SEQ ID NO:10, as determined using default parameter of a DNA sequence analysis software package developed by the Genetic Computer (Group (GCG) at the University of Wisconsin.

A heparanase overexpression system comprising a cell overexpressing heparanase catalytic activity, wherein said heparanase catalytic activity is effected by a recombinant heparanase sharing 7% homology with SEQ ID NO:10, as determined using default parameters of a DNA sequence analysis software package developed by the Genetic Computer Group (GCG) at the University of Wisconsin.