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AssigneeCedars-Sinai Medical Center
InventorsScott E. Plevy, Stephan R. Targan
Estimating the term…
The present invention provides serological and genetic methods of diagnosing a medically resistant clinical subtype of ulcerative colitis UC. The present invention provides a method of diagnosing a medically resistant clinical subtype of UC by determining the presence or absence of anti-Saccharomyces cerevisiae antibodies (ASCA) in a patient with UC, where the presence of ASCA indicates the medically resistant clinical subtype of UC. The present invention also provides a method of diagnosing a medically resistant clinical subtype of UC by determining the presence or absence of a TNFa2b1c2d4e1 haplotype in a patient with UC, where the presence of said TNFa2b1c2d4e1 haplotype indicates the medically resistant clinical subtype of UC. In addition, the invention provides a method of diagnosing a medically resistant clinical subtype of UC by determining the presence or absence of a TNFa2b1c2d4e1 haplotype in a patient with UC and determining the presence or absence of ASCA in the patient with UC, where the presence of said TNFa2b1c2d4e1 haplotype indicates the medically resistant clinical subtype of UC and the presence of ASCA independently indicates the medically resistant clinical subtype of UC. The invention further provides kits for diagnosing a medically resistant clinical subtype of UC containing antigen specific for ASCA and one or more oligonucleotide primers complementary to a nucleotide sequence flanking TNF microsatellite locus TNFa, TNFb, TNFc, TNFd or TNFe.
A method of diagnosing a medically resistant clinical subtype of ulcerative colitis (UC), comprising determining the presence or absence of anti-Saccharomyces cerevisiae antibodies (ASCA) in a patient with UC,
A method of diagnosing a medically resistant clinical subtype of UC, comprising determining the presence or absence of at least two TNF microsatellite alleles selected from the group consisting of TNFa2, TNFb1, TNFc2, TNFd4 and TNFe1 in a patient with UC,
A method of diagnosing a medically resistant clinical subtype of UC, comprising determining the presence or absence of a TNFa2b1c2d4e1 haplotype in a patient with UC,
A method of diagnosing a medically resistant clinical subtype of UC, comprising the steps of:
A kit for diagnosing a medically resistant clinical subtype of UC, comprising antigen specific for ASCA and one or more oligonucleotide primers complementary to a nucleotide sequence flanking a TNF microsatellite locus selected from the group consisting of TNFa, TNFb, TNFc, TNFd and TNFe.
Dependencies are inferred from the claim text.