ErbB3 antibodies
AssigneeGenentech, Inc.
InventorsRobert Akita, Mark Sliwkowski
Life of this patent
Estimating the term…
Abstract
Antibodies are disclosed which bind to ErbB3 protein and further possess any one or more of the following properties: an ability to reduce heregulin-induced formation of an ErbB2-ErbB3 protein complex in a cell which expresses ErbB2 and ErbB3; the ability to increase the binding affinity of heregulin for ErbB3 protein; and the characteristic of reducing heregulin-induced ErbB2 activation in a cell which expresses ErbB2 and ErbB3.
Claims36
An antibody which binds to ErbB3 protein and reduces heregulin-induced formation of an ErbB2-ErbB3 protein complex in a cell which expresses ErbB2 and ErbB3.
An antibody which binds to ErbB3 protein and increases the binding affinity of heregulin for ErbB3 protein.
An antibody which binds to ErbB3 protein and reduces heregulin-induced ErbB2 activation in a cell which expresses ErbB2 and ErbB3.
An antibody which binds to ErbB3 protein and reduces heregulin binding thereto.
Dependencies are inferred from the claim text.