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US 5,965,884 AGranted
Atmospheric pressure matrix assisted laser desorption
AssigneeThe Regents of the University of California
InventorsVictor V. Laiko, Alma L. Burlingame
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Abstract
An Atmospheric Pressure Matrix-Assisted Laser Desorption Ionization (AP-MALDI) apparatus is for connecting to a mass spectrometer. This apparatus provides an ion source using matrix-assisted laser desorption and ionization at or near atmospheric pressure. The apparatus has non-destructive ion source having the characteristics of versatility, simplicity.
Claims9
An atmospheric-pressure ionization device for connection to a spectrometer, comprising:
- a) an atmospheric-pressure ionization chamber;
- b) a sample support positioned within said ionization chamber;
- c) a sample placed on said sample support, and comprising an analyte embedded in an ionization-assisting matrix chosen such that said matrix facilitates ionization of said analyte to form analyte ions upon light-induced release of said analyte from said sample;
- c) a laser for illuminating said sample, to induce said release of said analyte from said sample, and to induce ionization of said analyte to form said analyte ions;
- and
- d) an interface connecting said ionization chamber and said spectrometer for capturing said analyte ions released from said sample and for transporting said analyte ions to said spectrometer.
3 more elements
Dependencies are inferred from the claim text.