Process for the preparation of a salt clavulanic acid
AssigneeSmithKline Beecham Corporation
InventorsMichael Alan Cook, Geoffrey Clive Webb
Life of this patent
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Abstract
A process for the preparation of a salt of clavulanic acid, wherein clavulanic acid in solution in a wholly or partly water-imiscible organic solvent is contacted in a region of high turbulence and/or shear stress, with a salt precursor compound to form a solution of the salt of clavulanic acid in an aqueous phase, then the organic solvent and aqueous phases are physically separated during a separation step, followed by a further processing step in which the said salt of clavulanic acid is isolated from solution as a solid.
Claims27
A process for the preparation of a salt of clavulanic acid, wherein clavulanic acid in solution in a wholly or partly water-imiscible organic solvent is contacted in a contact region which is a region of high turbulence and/or shear stress, with a salt precursor compound of a salt forming cation with a counter anion in solution or suspension, the counter anion being capable of exchange with clavulanate anion, in the presence of water, such that a solution of the salt of clavulanic acid in an aqueous phase is formed, then the organic solvent and aqueous phases are physically separated during a separation step, followed by a further processing step in which the said salt of clavulanic acid is isolated from solution as a solid.
Dependencies are inferred from the claim text.