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US 5,965,698 AGranted
Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
AssigneeVirginia Commonwealth University
InventorsHerbert J. Evans, R. Manjunatha Kini
Life of this patent
Estimating the term…
Abstract
Homologs and analogs of naturally-occurring polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are flanked by conformation-constraining moieties, such as proline or cysteine.
Claims5
A homolog of Factor V comprising no more than 30 amino acid residues and a Factor V protein-protein interaction site flanked on both termini by adjacent proline residues, wherein the proline residues are within 7 amino acid residues of its respective terminus of the protein-protein interaction site.
Dependencies are inferred from the claim text.