Desformoterol and process for its preparation
AssigneeSepracor Inc.
InventorChris Hugh Senanayake
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Abstract
The (R,R)-, (S,S)-, (R,S)-, (R,S)- isomers of 3-amino-4-hydroxy-.alpha.-[[[2-(4-methoxyphenyl)-1-methylethyl]amino]methy l]-benzenemethanol (D) ##STR1## are disclosed, as well as an efficient method for their stereoselective synthesis. A method and composition are also disclosed utilizing desformoterol (D) as a bronchodilator, having high selectivity for .beta..sub.2 receptors.
Claims31
A process for preparing a compound of formula ##STR19## comprising the sequential steps of:
- (a) providing a compound of formula;
- ##STR20## and (b) reducing said compound.
A process for preparing a salt of a compound of formula ##STR24## comprising the sequential steps of:
- (a) providing a compound of formula;
- ##STR25## and (b) reducing said compound in the presence of an acid.
A method of inducing bronchodilation or preventing bronchoconstriction comprising administering to an individual a therapeutically effective quantity of desformoterol, or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and desformoterol, or a pharmaceutically suitable salt thereof.
R,R-desformoterol or a pharmaceutically acceptable salt.
S,S-desformoterol or a pharmaceutically acceptable salt.
R,S-desformoterol or a pharmaceutically acceptable salt.
S,R-desformoterol or a pharmaceutically acceptable salt.
Dependencies are inferred from the claim text.