Pharmaceutical composition for treating peripheral circulation disorders
AssigneesTeigin Limited, Taisho Pharmaceutical Co., Ltd., Yutaka Mitzushima
InventorsHirofumi Tanabe, Toshinobu Murakami, Takashi Matsunaga, Shigeru Nakayama
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Abstract
A pharmaceutical composition for treating peripheral circulation disorders, which is an emulsion containing an isocarbacyclin having the following formula (1): ##STR1## wherein R.sup.1 is a hydrogen atom or alkyl group and R.sup.2 is a alkyl group which may be substituted with, a alkenyl group or alkynyl group which may be substituted with, or a cycloalkyl group which may be substituted with, in an amount of 0.2 to 1,000 .mu.g per ml of the composition, a vegetable oil in an amount of 0.05 to 0.5 g per ml of the composition, a phospholipid in an amount of 0.01 to 0.5 g per g of the vegetable oil, and water is provided.
Claims7
A method for treating chronic peripheral arterial occlusion comprising administering an emulsion containing an isocarbacyclin to a patient in need thereof, wherein the isocarbacyclin has the following formula (1):
- ##STR3## wherein R.sup.1 is a hydrogen atom or a C.sub.1 to C.sub.10 alkyl group and R.sup.2 is selected from the group consisting of substituted or unsubstituted C.sub.1 to C.sub.13 alkyl group, substituted or unsubstituted C.sub.2 to C.sub.13 alkenyl or alkynyl group, and substituted or unsubstituted C.sub.3 to C.sub.10 cycloalkyl group,
- in an amount of 0.2 to 1000 .mu.g per ml of the composition, a vegetable oil in an amount of 0.05 to 0.5 g per ml of the composition, a phospholipid in an amount of 0.01 to 0.5 g per g of the vegetable oil, and water.
A method for treating thromboangitis obliterans or arterioscle obliterans comprising administering an emulsion containing an isocarbacyclin to a patient in need thereof, wherein the isocarbacyclin has the following formula (1):
- ##STR4## wherein R.sup.1 is a hydrogen atom or a C.sub.1 to C.sub.10 alkyl group and R.sup.2 is selected from the group consisting of substituted or unsubstituted C.sub.1 to C.sub.13 alkyl group, substituted or unsubstituted C.sub.2 to C.sub.13 alkenyl or alkynyl group, and substituted or unsubstituted C.sub.3 to C.sub.10 cycloalkyl group,
- in an amount of 0.2 to 1000 .mu.g per ml of the composition, a vegetable oil in an amount of 0.05 to 0.5 g per ml of the composition, a phospholipid in an amount of 0.01 to 0.5 g per g of the vegetable oil, and water.
A method for treating ischemic ulcer accompanied with thromboangitis obliterans or arterioscle obliterans comprising administering an emulsion containing an isocabacyclin to a patient in need thereof, wherein the isocarbacyclin has the following formula (1):
- ##STR5## wherein R.sup.1 is a hydrogen atom or a C.sub.1 to C.sub.10 alkyl group and R.sup.2 is selected from the group consisting of substituted or unsubstituted C.sub.1 to C.sub.13 alkyl group, substituted or unsubstituted C.sub.2 to C.sub.13 alkenyl or alkynyl group, and substituted or unsubstituted C.sub.3 to C.sub.10 cycloalkyl group,
- in an amount of 0.2 to 1000 .mu.g per ml of the composition, a vegetable oil in an amount of 0.05 to 0.5 g per ml of the composition, a phospholipid in an amount of 0.01 to 0.5 g per g of the vegetable oil, and water.
Dependencies are inferred from the claim text.