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AssigneeTaiho Pharmaceutical Co., Ltd.
InventorsAtsushi Sato, Tetsuji Asao, Yuichi Hagiwara, Makoto Kitade, Yasundo Yamazaki
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The present invention is directed to an oxindole derivative represented by formula (1): ##STR1## (wherein R represents a methyl group or a methoxy group), and pharmaceuticals containing the compound. The compound exhibits excellent granulation inhibiting activity while providing minimal liver toxicity and is useful as a pharmaceutical in the prevention and treatment of articular rheumatism, arteriosclerosis, hepatocirrhosis, etc., and also in the prevention and treatment of arthrosis deformans, psoriasis, gout, nephritis, angiitis, inflammatory intestinal diseases (ulcerative colitis, Crohn's disease), bronchitis, and chronic granulomatosis, etc.
An oxindole derivative represented by formula (1):
A preventive and therapeutic method for arteriosclerosis and articular rheumatism caused by granulation, comprising administering to a patient in need thereof an oxindole derivative represented by formula (1):
Dependencies are inferred from the claim text.