Substituted imidazoles useful in the treatment of inflammatory disease

A compound of Formula I ##STR37## wherein:

• R.sub.1 is phenyl, substituted phenyl where the substituents are selected from the group consisting of C.sub.1-5 alkyl, halogen, nitro, trifluoromethyl, and nitrile, or pyridinyl;
• R.sub.2 is phenyl, substituted phenyl where the substituents are selected from the group consisting of C.sub.1-5 alkyl, halogen, nitro, trifluoromethyl, and nitrile or pyridinyl where the pyridinyl is optionally C.sub.1-4 alkyl substituted;
• R.sub.3 is hydrogen, SEM, C.sub.1-5 alkoxycarbonyl, aryloxycarbonyl, arylC.sub.1-5 -alkyloxycarbonyl, arylC.sub.1-5 alkyl, substituted arylC.sub.1-5 alkyl where the aryl substituents are independently selected from one or more members of the group consisting of C.sub.1-5 alkyl, C.sub.1-5 alkoxy, halogen, amino, C.sub.1-5 alkylamino, and diC.sub.1-5 alkylamino, phthalimidoC.sub.1-5 -alkyl, aminoC.sub.1-5 alkyl, diaminoC.sub.1-5 alkyl, succinimidoC.sub.1-5 alkyl, C.sub.1-5 alkylcarbonyl, arylcarbonyl, C.sub.1-5 alkylcarbonylC.sub.1-5 alkyl, aryloxycarbonylC.sub.1-5 alkyl;
• R.sub.4 is (A)--(CH.sub.2).sub.q --X where:
• A is vinylene, ethynylene or ##STR38## where R.sub.5 is selected from the group consisting of hydrogen, C.sub.1-5 alkyl, phenyl and phenylC.sub.1-5 alkyl;
• q is 0-9;
• X is selected from the group consisting of hydrogen, hydroxy, vinyl, substituted vinyl where one or more substituents are selected from the group consisting of fluorine, bromine, chlorine and iodine), ethynyl, substituted ethynyl (where the substituents are selected from one or more of the group consisting of fluorine, bromine chlorine and iodine, C.sub.1-5 alkyl, substituted C.sub.1-5 alkyl where the alkyl substituents are selected from the group consisting of one or more C.sub.1-5 alkoxy trihaloalkyl, phthalimido and amino, C.sub.3-7 cycloalkyl, C.sub.1-5 alkoxy, substituted C.sub.1-5 alkoxy where the alkyl substituents are selected from the group consisting of phthalimido and amino, phthalimidooxy, phenoxy, substituted phenoxy (where the phenyl substituents are selected from the group consisting of C.sub.1-5 alkyl, halogen and C.sub.1-5 alkoxy), phenyl, substituted phenyl where the phenyl substituents are selected from the group consisting of C.sub.1-5 alkyl, halogen and C.sub.1-5 alkoxy, arylC.sub.1-5 alkyl, substituted arylC.sub.1-5 alkyl where the aryl substituents are selected from the group consisting of C.sub.1-5 alkyl, halogen and C.sub.1-5 alkoxy, arylhydroxyC.sub.1-5 alkyl amino, C.sub.1-5 alkylamino, diC.sub.1-5 alkylamino, nitrile, oxime, benxyloxyimino, C.sub.1-5 alkyloxyimino, phthalimido, succinimido, C.sub.1-5 alkylcarbonyloxy, phenylcarbonyloxy, substituted phenylcarbonyloxy where the phenyl substitutents are selected from the group consisting of C.sub.1-5 alkyl, halogen and C.sub.1-5 alkoxy, phenylC.sub.1-5 alkylcarbonyloxy, where the phenyl substitutents are selected from the group consisting of C.sub.1-5 alkyl, halogen and C.sub.1-5 alkoxy, aminocarbonyloxy, C.sub.1-5 alkylaminocarbonyloxy, diC.sub.1-5 alkylaminocarbonyloxy, C.sub.1-5 alkoxycarbonyloxy, substituted C.sub.1-5 alkoxycarbonyloxy where the alkyl substituents are selected from the group consisting of methyl, ethyl, isopropyl and hexyl, phenoxycarbonyloxy, substituted phenoxycarbonyloxy where the phenyl substituents are selected from the group consisting of C.sub.1-5 alkyl, C.sub.1-5 alkoxy, and halogen, C.sub.1-5 alkylthio, substituted C.sub.1-5 alkylthio where the alkyl substituents are selected from the group consisting of hydroxy and phthalimido, C.sub.1-5 alkylsulfonyl, phenylsulfonyl, substituted phenylsulfonyl where the phenyl substituents are selected from the group consisting of bromine, fluorine, chloride, C.sub.1-5 alkoxy and trifluoromethyl;
• with the proviso:
• if A is ##STR39## q is 0 and X is H, R.sub.3 may not be SEM;
• and pharmaceutically acceptable salts thereof.