Back to results
US 5,965,575 AGranted
N-aryl piperidine compounds as 5HT.sub.1B antagonists
AssigneeAdir et Compagnie
InventorsJean-Louis Peglion, Bertrand Goument, Mark Millan, Alain Gobert, Valerie Audinot
Life of this patent
Estimating the term…
Abstract
New N-arylpiperidine compounds of formula: ##STR1## wherein: A, m, R, E, n and Ar are as defined in the description, the isomers thereof and the addition salts thereof with a pharmaceutically acceptable acid, and medicinal products containing the same are useful in the treatment of disorders involving the serotininergic system.
Claims7
N-arylpiperidine compounds selected from those of formula I:
- ##STR11## wherein:
- m represents 1 to 5 inclusive;
- n represents 1 or 2;
- R represents hydrogen, straight-chain or branched (C.sub.1 -C.sub.5)alkyl, or aralkyl in which the alkyl moiety contains 1 to 5 carbon atoms inclusive in straight or branched chain;
- E represents hydrogen or methyl;
- Ar represents:
- ##STR12## X being hydrogen or halogen and A represents:
- ##STR13## wherein:
- X.sub.1, X.sub.2, X.sub.3, and X.sub.4, which may be identical or different,
- each represents hydrogen or halogen, (C.sub.1 -C.sub.5)alkyl, or (C.sub.1 -C.sub.5)alkoxy, each of which is straight-chain or branched, trifluoromethyl, hydroxy, cyano, or nitro, or ##STR14## wherein :
- R.sub.1, R.sub.2, and R.sub.3, which may be identical or different, each represents hydrogen or straight-chain or branched (C.sub.1 -C.sub.5)alkyl, and R.sub.4 represents a straight-chain or branched (C.sub.1 -C.sub.5)alkyl, or
- a pair of X.sub.1, X.sub.2, X.sub.3, and X.sub.4 adjacent to one another form, together with the carbon of the phenyl to which they are bonded, a 5-membered or 6-membered ring comprising atoms selected from carbon, oxygen, nitrogen, and sulphur,
- where they exist in the form of a racemic mixture or in the form of optical isomers,
- and physiologically-tolerable acid addition salts thereof.
11 more elements
Dependencies are inferred from the claim text.