US 5,965,573 A · Compositions and methods for treating bone deficit conditions

Abstract

Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 .ANG., are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

Claims15

Dependent claims

A method to treat a condition in a vertebrate animal characterized by a deficiency in, or need for, bone growth replacement and/or an undesirable level of bone resorption, which method comprises administering to a vertebrate subject in need of such treatment an effective amount of a compound of the formula:

##STR7## wherein each R.sup.1 is independently a non-interfering substituent;
m is an integer of 0-5;
each Z is independently N or CR, where R is H or alkyl (1-6C), with the proviso that at least one Z must be a heteroatom and at least one Z must be CR;
L is a linker;
and
Ar.sup.2 is a substituted or unsubstituted phenyl, a substituted or unsubstituted naphthyl, a substituted or unsubstituted aromatic system containing a 6-membered heterocycle, or a substituted or unsubstituted aromatic system containing a 5-membered heterocycle.

3 more elements

Dependencies are inferred from the claim text.

Compositions and methods for treating bone deficit conditions

Life of this patent

Compositions and methods for treating bone deficit conditions

Life of this patent

Abstract

Claims15