Substituted piperazines and piperidines as central nervous system agents
AssigneeWarner-Lambert Company
InventorsShelly A. Glase, Terri S. Purchase, Lawrence D. Wise
Life of this patent
Estimating the term…
Abstract
Substituted piperazines and piperidines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopamine antagonists and antipsychotic agents.
Claims6
A compound of Formula I ##STR11## whereas R is 4-,5-,6-, or 7-benzo[b]furanyl,
- 4-,5-,6-, or 7-benzo[b]thienyl,
- 4-,5-,6-, or 7-indolyl,
- 2-,3-,4-,5-,6-,7-, or 8-quinolinyl,
- or
- 2-,3-,4-,5-,6-,7-, or
- 8-isoquionlinyl;
- or a pharmaceutically acceptable acid addition salt thereof.
A method of treating psychoses comprising administering to a host suffering therefrom a therapeutically effective amount of a compound of Formula I ##STR12## wherein R is a phenyl group or phenyl group substituted by 1 to 4 substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen, nitro, amino, and cyano,
- 2-, 3- or 4-pyridinyl,
- 4-, 5-, 6-, or 7-benzo[b]furanyl,
- 4-, 5-, 6-, or 7-benzo[b]thienyl,
- 4-, 5-, 6-, or 7-indolyl,
- 2-, 3-, 4-, 5-, 6-, 7-, or 8-isoquinolinyl;
- or a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.