Pyrrolidine derivatives

A pyrrolidine represented by formula (4):

• ##STR19## wherein R3 represents a phenyl group which may be substituted with a substituent(s) selects from the group consisting of a lower alkyl group, a lower alkoxy group, phenoxy, methylenedioxy, a halogen atom, hydroxy, mercapto, an alkylthio group, nitro and a mono- and di-lower alkylamino group;
• p represents an integer of 1 to 3;
• and,
• Y2 represents a pyridyl group or a morpholino group, each of which may be substituted with a substituent(s) selected from the group consisting of a lower alkyl group, a lower alkoxy group, phenoxy, methylenedioxy, a halogen atom, hydroxy, mercapto, an alkylthio group, nitro and a mono- and di-lower alkylamino group;
• or a salt thereof.

A pyrrolidine represented by formula (1):

• ##STR20## wherein:
• R1 represents a pyridyl group or a morpholino group, each of which may be substituted with a substituent(s) selected from the group consisting of a lower alkyl group, a lower alkoxy group, phenoxy, methylenedioxy, a halogen atom, hydroxy, mercapto, an alkylthio group, nitro and a mono- and di-lower alkylamino group;
• each of n and m represents an integer and the sum of n and m is an integer of 0 to 2;
• each of X and E represents oxygen, NR' (wherein R' is hydrogen or a lower alkyl group having 1 to 6 carbon atoms), sulfur, phenylene, CH.dbd.CH or CH.sub.2 ;
• A represents an amino acid residue or an amino acid residue, which functional group may be optionally protected, or a glycine residue which may be substituted at the amino moiety thereof with a substituent selected from the group consisting of glycine, sarcosine, N-benzylycine, N-cyclohexylglycine, N-cyclohexylnmethylglycine, N-isopropylglycine and N-isobutylglycine;
• and
• Y1 represents a cycloalkyl group having 3 to 8 carbon atoms;
• or a salt thereof.

A pyrrolidine represented by formula (2):

• ##STR21## wherein:
• R2 represents a pyridyl group or a morpholino group, each of which may be substituted with a substituent(s) selected from the group consisting of a lower alkyl group, a lower alkoxy group, phenoxy, methylenedioxy, a halogen atom, hydroxy, mercapto, an alkylthio group, nitro and a mono- and di-lower alkylamino group;
• each of n and m represents an integer and the sum of n and m is an integer of 0 to 2;
• each of X and B represents oxygen, NR' (wherein R' is hydrogen or a lower alkyl group having 1 to 6 carbon atoms), sulfur, phenylene, CH.dbd.CH or CH.sub.2 ;
• and,
• Y1 represents a cycloalkyl group having 3 to 8 carbon atoms:
• or a salt thereof.