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US 5,965,539 AGranted
Inhibitors of prenyl transferases
AssigneeUniveristy of Pittsburgh
InventorsSaid Sebti, Andrew Hamilton
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Abstract
Compounds which inhibit prenyl transferases, particularly farnysyltransferase and geranylgeranyl transferase I, processes for preparing the compounds, pharmaceutical compositions containing the compounds, and methods of use.
Claims26
A peptidomimetic of the formula:
- C.beta.X
- wherein
- C is a 3-mercapto-2-amino-propylamino group;
- X is an amino acid;
- and
- .beta. is a residue of an optionally substituted aminobenzoic acid or an optionally substituted aminonaphthoic acid.
3 more elements
A compound of the formula:
- wherein R represents H or CH.sub.3 ;
- or OR, taken together with the carbonyl group to which it is bonded, represents a lipophilic esterase-sensitive moiety,
- and R.sup.1 represents H or a substituted or unsubstituted phenyl group.
A compound of the formula ##STR15## wherein R represents H or CH.sub.3 ;
- or OR, taken together with the carbonyl group to which it is bonded, represents a lipophilic esterase-sensitive moiety,
- and R.sup.1 represents H or a substituted or unsubstituted phenyl group.
A compound of the formula ##STR16## wherein R represents H or CH.sub.3 ;
- or OR, taken together with the carbonyl group to which it is bonded, represents a lipophilic esterase-sensitive moiety.
A compound of the formula ##STR17## wherein R represents H or CH.sub.3 ;
- or OR, taken together with the carbonyl group to which it is bonded, represents a lipophilic esterase-sensitive moiety,
- and R.sup.1 represents H, CH.sub.3 or OCH.sub.3.
Dependencies are inferred from the claim text.