Mage-3 peptides presented by HLA class II molecules
AssigneeLudwig Institute for Cancer Research
InventorsPascal Chaux, Vincent Stroobant, Thierry Boon-Falleur, Pierre van der Bruggen
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Abstract
The invention describes the HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4.sup.+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-3 gene.
Claims11
An isolated HLA class II-binding peptide comprising the amino acid sequence of SEQ ID NO:11, or a functional variant thereof.
A composition comprising an isolated MAGE-3 HLA class I-binding peptide and an isolated MAGE-3 HLA class II-binding peptide.
Dependencies are inferred from the claim text.