Back to results
US 5,965,532 AGranted
Multivalent compounds for crosslinking receptors and uses thereof
AssigneeTrustees of Tufts College
InventorWilliam W. Bachovchin
Life of this patent
Estimating the term…
Abstract
Synthetic crosslinking homobivalent and heterobivalent compounds have been designed and developed. These compounds are low in molecular weight, have antagonistic or agonistic activity, and induce the association between two identical or similar natural receptors (homobivalent compounds) or induce the association between two different natural receptors (heterobivalent compounds).
Claims11
A compound having the structure:
- ##STR14## (a) wherein B is boron, (b) wherein each of Y1 and Y2 is independently selected from the group consisting of a hydroxyl moiety and a reactive moiety that converts to a hydroxyl moiety under physiologic conditions,
- (c) wherein -A3-A4- has the structure ##STR15## (d) wherein ##STR16## is an amino acid having a structure selected from the the group consisting of:
- ##STR17## wherein R represents the side chain of the amino acid;
- (e) wherein L is a linker molecule (i) having a molecular weight ranging between about 100 daltons and about 2000 daltons, and (ii) having a span ranging from about 20 .ANG. to about 300 .ANG., and
- (f) wherein P is a peptide (i) ranging from 3 to 30 amino acids and (ii) that binds to a naturally occurring receptor expressed on the surface of a cell involved in immune system modulation,
- wherein the compound binds to at least one DPIV protein.
3 more elements
Dependencies are inferred from the claim text.