Therapeutic uses of keratinocyte growth factor
AssigneeAmgen Inc.
InventorsGlenn Francis Pierce, Regina Mae Housley, Charles Frederick Morris
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Abstract
Based on extensive in vivo studies in animals, it has now been discovered that KGF stimulates proliferation, growth and differentiation in various cells of epithelial tissue, besides keratinocytes. This better understanding of the biological effects of KGF in vivo enables the use of this polypeptide as a therapeutic agent, suitably formulated in a pharmaceutical composition, for the specific treatment of disease states and medical conditions afflicting tissues and organs such as the dermal adnexae, the liver, the lung, and the gastrointestinal tract.
Claims23
A method for reducing loss of hair by preventing chemotherapy-induced alopecia, comprising administering a therapeutically effective amount of a keratinocyte growth factor (KGF) product to a patient in need thereof.
A method for the treatment of hyaline membrane disease, comprising administering a therapeutically effective amount of a keratinocyte growth factor (KGF) product to a patient in need thereof.
Dependencies are inferred from the claim text.