Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor
AssigneesBoard of Regents, The University of Texas, Schering Corporation
InventorsRobert E. Garfield, Krzysztof Chwalisz, Radoslaw Bukowski, Chandra Yallamp'al Li
Life of this patent
Estimating the term…
Abstract
Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in further combination with one or more of a cyclooxygenase inhibitor, a PGI.sub.2 -mimetic, a thromboxane (TXA.sub.2) inhibitor, a compound possessing TXA.sub.2 -agonistic and TXA.sub.2 -inhibiting properties, a compound possessing TXA.sub.2 -antagonistic and PGI.sub.2 -memetic activities, and a TXA.sub.2 antagonist.
Claims32
A method of inhibiting the nitric oxide dependent contractility of the uterus of a non-pregnant female mammal or a pregnant female mammal suffering from preeclampsia accompanied or unaccompanied by preterm labor, comprising administering a nitric oxide synthase substrate and/or a nitric oxide donor in an amount effective to inhibit uterine contractility.
Dependencies are inferred from the claim text.