Recombinant human alph-fetoprotein as an immunosuppressive agent
AssigneeMcGill University
InventorRobert A. Murgita
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Abstract
Disclosed are methods of inhibiting autoreactive immune cell proliferation in a mammal, involving administering to the mammal a therapeutically effective amount of recombinant human alpha-fetoprotein or an immune cell anti-proliferative fragment or analog thereof.
Claims15
A method of inhibiting autoreactive immune cell proliferation in a mammal, said method comprising administering to said mammal a therapeutically effective amount of recombinant human alpha-fetoprotein or a fragment thereof comprising Domain I, Domain II, Domain III, Domain I+II, Domain II+III, or Fragment I, wherein said recombinant alpha-fetoprotein is produced in a prokaryotic cell and is unglycosylated.
A method of treating an autoimmune disease in a mammal, said method comprising administering to said mammal a therapeutically effective amount of recombinant human alpha-fetoprotein or a fragment thereof comprising Domain I, Domain II, Domain III, Domain I+II, Domain II+III, or Fragment I, wherein said recombinant alpha-fetoprotein is produced in a prokaryotic cell and is unglycosylated.
Dependencies are inferred from the claim text.