Analogs of viscosin and uses thereof
AssigneePeptide Technologies Corporation
InventorsTerrance Burke, Jr., Bhaskar Chandrasekhar, Martha Knight
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Abstract
This invention is directed to the analogs of viscosin, pharmaceutical compositions thereof and to methods of using viscosin and analogs thereof as biosurfactants and as antibacterial, antiviral and antitrypanosomal therapeutic compounds. In particular, compositions that inhibit the growth of the pathogens Mycobacterium tuberculosis, Herpes Simplex Virus 2 and/or Trypanosoma cruzi are disclosed.
Claims24
A linear viscosin analog selected from the group consisting of:
- D-3-Hydroxydecanoyl-L-Leu-D-Glu-NH.sub.2 ;
- or ##STR24## .
A viscosin analog having the following formula:
- ##STR25## wherein X is D- or L-Lys or Orn, and wherein R is D-3-hydroxydecanoyl-L-Leu-D-Glu, Decanoyl-L-Leu-D-Glu, Octadecanoyl, linear C.sub.2 to C.sub.22 amides, or D-3-hydroxydecanoyl-L-X.sub.1 -X.sub.2, wherein X.sub.1 is Ile, Val, Gly, or Norisoleucine and wherein X.sub.2 is D-Asp, D-.gamma.Glu, D-.beta.Asp, Succinic acid, or dicarboxylic acid.
A viscosin analog having the following formula:
- ##STR26## wherein X is Dbu, and wherein R is D-3-hydroxydecanoyl-L-Leu-D-Glu, Decanoyl-L-Leu-D-Glu, Octadecanoyl, linear C.sub.2 to C.sub.22 amides, or D-3-hydroxydecanoyl-L-X.sub.1 -X.sub.2, wherein X.sub.1 is Ile, Val, Gly, or Norisoleucine and wherein X.sub.2 is D-Asp, D-.gamma.Glu, D-.beta.Asp, Succinic acid, or dicarboxylic acid.
A viscosin analog having the following formula:
- ##STR27## wherein X is D-allo-Thr, D-Thr, D-Ser, or Homoserine and wherein R is D-3-hydroxydecanoyl-L-Leu-D-Glu, Decanoyl-L-Leu-D-Glu, Octadecanoyl, linear C.sub.2 to C.sub.22 amides, or D-3-hydroxydecanoyl-L-X.sub.1 -X.sub.2, wherein X.sub.1 is Ile, Val, Gly, or Norisoleucine and wherein X.sub.2 is D-Asp, D-.gamma.Glu, D-.beta.Asp, Succinic acid, or dicarboxylic acid, provided that X is not D-allo-Thr when R is D-3-hydroxydecanoyl-L-Leu-D-Glu.
A compound having the following formula:
- ##STR28## wherein R is C.sub.2 -C.sub.22 aliphatic amides;
- C.sub.2 -C.sub.22 fatty acyl amides;
- D-3-hydroxydecanoyl-L-X.sub.1 -D-X.sub.2 -NH;
- or
- Decanoyl-L-X.sub.1 -D-X.sub.2 -NH,
- X.sub.1 is a neutral amino acid and wherein X.sub.2 is an acidic or a neutral amino acid.
Dependencies are inferred from the claim text.