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US 5,965,456 AGranted
Analyte detection
AssigneeBiacore AB
InventorsMagnus Malmqvist, Gregory Paul Winter
Life of this patent
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Abstract
Disclosed is apparatus for detecting the presence of an analyte of interest in a sample, comprising an immobilised binding partner comprising a solid support and a reversibly binding receptor which is capable of binding to the analyte of interest thereby causing a measurable change in a property of the immobilised partner, and detection means for detecting the measurable change and a method for detecting the presence of an analyte of interest.
Claims10
An apparatus for detecting the presence of an analyte of interest in a solution sample, comprising:
- an immobilized binding partner comprising a solid support and a reversibly binding receptor which is capable of binding to the analyte of interest, such binding forming a receptor/analyte complex and thereby causing a measurable change in a property associated with the immobilized binding partner;
- and
- a detection means for detecting the measurable change, wherein the receptor/analyte complex has a dissociation rate constant of greater than 3.2.times.10.sup.-2 per second such that the apparatus responds rapidly to changes in analyte concentration and is suitable for on-line, real time measurement of the analyte.
Dependencies are inferred from the claim text.